Since I updated to 10.6.6, the Optimus Maximus craps out after a few moments to a few minutes of use. Basically I get the message "the disk was ejected, etc, etc" basically suggesting that the little SD card was ejected improperly.... though it's still plugged in.

The keyboard still works to type... but any programmed keys don't work, and none of the layers change based on program or key press anymore.

Anyone have any ideas?

This seems to be a known problem. See here.

Seems the solution is to downgrade the keyboard firmware to 0.76b if you haven't already tried.