It does work. Its all about creating layers and setting the correct conditions. For example I have a photoshop layer and the conditions are set to activate the layer when Photoshop is active. In other words when PS is the front most application running then my layout will appear. If I click into another application or into the finder, the layout disappears - click back to photoshop and viola, PS layout appears. Awesome!
Conditions are the most important part of the maximus configurater. If you dont set these correctly then your keyboard is useless (for now until keymapping and more features are added). Try experimenting with conditions - you'll be happy you did